Angels with Filthy Souls is a fictional gangster film which exists within the Home Alone Universe, which was made specifically for the film. A sequel to this film called "Angels with Even Filthier Souls" appears in Home Alone 2: Lost in New York. The main character of both films is called Johnny.
Kevin, after being left home alone by his family, finds a Video tape of "Angels with Filthy Souls" and is seen watching it while eating a huge bowl of ice cream. Johnny, a gangster at an office, is met by Snakes, a gangster sent by the head gangster, Acey. Snakes asks for money Johnny owed for "the stuff". Johnny said, "Too bad Acey ain't in charge no more" and implies he's not about to give Snakes any money. Snakes shows discomfort when Johnny says that Acey is upstairs taking a bath, and almost immediately, Johnny pulls out his Tommy gun. Johnny tells Snakes to get out before he counts to ten. However, Johnny cuts the count short, counting to two, then jumping straight to ten ("One, two...TEN!"), and, while laughing maniacally, shoots rapid bullets at Snakes, killing him. Johnny stares at the corpse and says, "Keep the change, ya filthy animal!". Kevin then paused the video and shouted for his mom.
To thwart the burglars, Kevin plays the home video of Angels with Filthy Souls to trick them into thinking there are armed, dangerous adults in his house. He also uses video to trick a pizza delivery guy to make him sure that a Johnny was ordering the pizza. People who heard the video thought that a man was going to shoot, causing them to run away.
The title is likely a reference to the 1938 film Angels with Dirty Faces. There is also a sequel to the film, Angels with Even Filthier Souls, in this film's sequel, which aids Kevin as well.